Anavar was the old U.S. brand name for the oral steroid oxandrolone, that was first produced in 1964 by the drug manufacturer Searle. It was designed as an extremely mild anabolic, that could even be safely used as a growth stimulant in children. One immediately thinks of the standard worry, "steroids including oxandrolone will stunt growth". But it is actually the excess estrogen produced by most steroids that is the culprit, just as it is the reason why women stop growing Anavar sooner and have a shorter average stature than men. Anavar will not aromatize, and therefore the anabolic effect of the Anavar compound can actually promote linear growth. Women usually tolerate this drug well at low doses, and at one time Anavar was prescribed for the treatment of osteoporosis. But the atmosphere surrounding steroids began to change rapidly in the 1980's, and prescriptions for Oxandrolone began to drop. Lagging sales probably led Searle to discontinue manufacture in 1989, and it had vanished from U.S. pharmacies until recently. Oxandrolone tablets are again available inside the U.S. by BTG, bearing the new brand name Oxandrin. BTG purchased rights to Anavar from Searle and is now manufactured for the new purpose of treating HIV/AIDS related wasting syndrome. Many welcomed this announcement, as Anavar had gained a very favorable reputation among athletes over the years.
Oxandrolone is a weak steroid with only a slight androgenic component. It has been shown that Oxandrolone, when taken in reasonable dosages, rarely has any side effects. This is appreciated since Oxandrolone was developed mostly for women and children. Oxandrolone is one of the few steroids which does not cause an early stunting of growth in children since it does not prematurely close the epiphysial growth plates. For this reason Oxandrolone is mostly used in children to stimulate growth and in women to prevent osteoporosis. Oxandrolone causes very light virilization symptoms, if at all. This characteristic makes Oxandrolone a favored remedy for female athletes since, at a daily dose of 10-30 mg, masculinizing symptoms are observed only rarely.
Bodybuilders and powerlifters, in particutar, like Oxandrolone for three reasons. First, Oxandrolone causes a strong strength gain by stimulating the phosphocreatine synthesis in the muscle cell without depositing liquid (water) in the joints and the muscles. Powerlifters and weightlifters who do not want to end up in a higher weight class take advantage of this since it allows them to get stronger without gaining body weight at the same time. The combination of Oxandrolone and 20-30 mg Holotestin daily has proven to be very effective since the muscles also look harder. Similarly good results can be achieved by a simultaneous intake of Oxandrolone and 120-140 mcg Clenbuterol per day. Although Oxandrolone itself does not cause a noticeable muscle growth it can clearly improve the muscle-developing effect of many steroids. Deca-Durabolin, Dianabol (D-bol) and the various testosterone compounds, in particular, combine well with Oxandrolone to achieve a "mass buildup" because the strength gain caused by the intake of these highly tissue-developing and liquid-retaining substances results in an additional muscle mass. A stack of 200 mg Deca-Durabolin/week, 500 mg Testoviron Depot/week, and 25 mg Oxandrolone/day leads to a good gain in strength and mass in most athletes. Deca-Durabolin has a distinct anabolic effect and stimulates the synthesis of protein; Oxandrolone improves the strength by a higher phosphocreatine synthesis; and Testoviron Depot inereases the aggressiveness for the workout and accelerates regeneration.
The second reason why Oxandrolone is so popular is that this compound does not aromatize in any dosage. As already mentioned, a certain part of the testosterone present in the body is converted into estrogen. This aromatization process, depending on the predisposition, can vary distinctly from the athlete to another. Oxandrolone is one of the few steroids which cannot aromatize to estrogen. This characteristic has various advantages for the athlete. With Oxandrolone the muscle system does not get the typical watery appearance as with many steroids, thus making it very interesting during the preparation for a competiton. In this phase it is especially important to keep the estrogen level as low as possible since estrogen programs the body to store water even if the diet is calorie-reduced. In combination with a diet, Oxandrolone helps to make the muscles hard and ripped. Although Oxandrolone itself does not break down fat, it plays an indirect role in this process because the substance often suppresses the athlete's appetite. Oxandrolone can also cause some bloating which in severat athletes results in nausea and vomiting when the tablets are taken with meals. The package insert of the Italian Oxandrolone notes its effect on the activity of the gastrointestinal tract. Some athletes thus report continued diarrhea. Although these symptoms are not very pleasant they still help the athlete break down fat and become harder. Those who work out for a competition or are interested in gaining quality muscles should combine Oxandrolone with steroids such as Winstrol, Parabolan, Masterject, Primobolan Depot, and Testosterone propionate. A stack of 50 mg Winstrol every two days, 50 mg Testosterone propionate every two days, and 25 mg Oxandrolone every day has proven effective. Another advantage of Oxandrolone's nonaromatization is that athletes who suffer from high blood pressure or develop gynecomastia of the thymus glands when taking stronger androgenic steroids will not have these side effects with a this compound. The Oxandrolone/Deca-Durabolin stack is a welcome alternative for this group of athletes or for athletes showing signs of poor health during mass buildup with testosterone, Dianabol (D-bol), or Anadrol. Athletes over forty should predominantly use Oxandrolone.
The third reason which speaks well for an intake of Oxandrolone is that even in a very high dosage this compound does not influence the body's own testosterone production. To make this clear: Oxandrolone does not suppress the body's own hormone production. The reason is that it does not have a negative feedback mechanism on the hypothalamohypophysial testicular axis, meaning that during the intake of Oxandrolone, unlike during the intake of most anabolic steroids, the testes signal the hypothalamus not to reduce or to stop the release of GnRH (gonadotropin releasing hormone) and LHRH (luteinizing hormon releasing hormone). This special feature of Oxandrolone can be explained by the fact that the substance is not converted into.
For this reason Oxandrolone combines very well with Andriol, since Andriol does not aromatize in a dosage of up to 240 mg daily and has only slight influence on the hormone production. The daily intake of 280 mg Andriol and 25 mg Oxandrolone results in a good gain in strength and, in steroid novices, also in muscle mass without excessive water retention and without significant influence on testosterone production. As for the dosage of Oxandrolone, 8-12 tablets in men and 5-6 tablets in women seems to bring the best results. The rule of thumb to take 0.125mg/pound of body weight daily has proven successful in clinical tests. The tablets are normally taken two to three times daily after meals thus assuring an optimal absorption of the substance. Those who get the already discussed gastrointestinal pain when taking Oxandrolone are better off taking the tablets one to two hours after a meal or switching to another campound.
Since Oxandrolone is only slightly toxic and usually shows few side effects it is used by several athletes over a prolonged period ot time. However Oxandrolone should not be taken for several consecutive months, since, as with almost all oral steroids it is 17-alpha alkylated and thus liver toxic. Oxandrolone is an all purpose remedy which, depending on the athlete's goal, is very versatile. Women who react sensitively to the intake of anabolic steroids achieve good results when combining Oxandrolone/Primobolan Tabs and/or Clenbuterol, without suffering from the usual virilization symptoms. Women, however should not take more than 6 tablets daily. Otherwise, androgenic-caused side effects such as acne, deep voice, clitorial hypertrophy or increased growth of body hair can occur.